Using the model organism Caenorhabditis elegans, biologists have identified molecular mechanisms that cause DNA damage in sperm and contribute to male infertility after exposure to heat. In humans, th...
Why Heat Stress Damages Sperm
Human Uterus Colonized by Clones With Cancer-Causing Mutations that Occur Early in Life
Many cells in the inner lining of the uterus carry “cancer-causing” mutations that often occur early in life, according to scientists at the Wellcome Sanger Institute, the University of Cambridge,...
Researchers Identify Dual Origin of Cells that Control Puberty and Reproduction
Researchers at the Francis Crick Institute have demonstrated that gonadotrophs, cells in the pituitary gland that play an important role in puberty and reproduction, originate from two different popul...
Early Detection of Endometriosis: Research Into New Diagnostic Methods
Endometriosis is a common, debilitating chronic disease that affects more than 190 million women worldwide. Early diagnosis remains a major clinical and health policy challenge. The average time to di...
Scientists Discover New Epigenetic Switch
Researchers have discovered that a DNA modification called 5-formylcytosine (5fC) acts as an activating epigenetic switch that triggers genes in early embryonic development. This discovery shows that ...
Improved Model System Enables Researchers to Study Embryonic Development
Research conducted by doctoral student Bohan Chen in the laboratory of Idse Heemskerk at the Department of Cell and Developmental Biology at the University of Michigan Medical School and his colleague...
New Stem Cell Model Provides Insights Into the Development of the Human Amniotic Sac
Researchers at the Francis Crick Institute have developed a new stem cell model of the mature human amniotic sac that replicates the development of the tissues that support the embryo two to four week...
A Simple Mouth Swab Before IVF is Expected to Increase the Success Rate
Approximately 15 percent of all couples of childbearing age are involuntarily childless. An important reason why so many people rely on artificial insemination is that more and more couples are postpo...
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